New Gastroparesis Treatments In Wesley Chapel, FL

If you live in Wesley Chapel and you’ve been handed metoclopramide and a list of foods to avoid, there is a next step. It starts with proving your pylorus is the problem before anyone treats it. Dr. Gopal Grandhige, a fellowship-trained foregut surgeon, screens every gastroparesis patient against a four-part standard and performs endoscopic pyloromyotomy only for the patients who clear it. Consults are usually scheduled within two weeks.

What Actually Changed in Gastroparesis Treatment in 2025 and 2026

Three things changed, and only one of them is a treatment you can start today.

The guidelines tightened. In September 2025 the American Gastroenterological Association published its clinical practice guideline on gastroparesis, with 12 conditional recommendations. It advised against 2-hour gastric emptying testing and in favor of the full 4-hour study. It backed metoclopramide or erythromycin as first-line drug therapy. It advised against domperidone, prucalopride, aprepitant, nortriptyline, buspirone, and cannabidiol as first-line options. And it advised against the routine initial use of G-POEM or gastric electrical stimulation, reserving both for patients whose symptoms persist after medical therapy.

A new oral drug cleared Phase 2b. Naronapride is a locally acting gut prokinetic that works on two targets at once, 5-HT4 agonism and D2 antagonism. The global Phase 2b MOVE-IT trial enrolled 328 adults with moderate-to-severe idiopathic or diabetic gastroparesis and objective delayed emptying. Results announced in May 2026 showed the 20 mg and 40 mg three-times-daily doses hit the primary endpoint on the ANMS GCSI-DD core symptom score. Roughly 15 to 20 percent more patients on those doses reached a clinically meaningful improvement than on placebo. The 40 mg dose gave no added benefit over 20 mg. In June 2026 the sponsors confirmed they’re advancing into late-stage Phase 3 studies toward a US filing. Naronapride is not available outside of a trial.

Tradipitant is approved, but not for this. The FDA approved tradipitant as Nereus on December 30, 2025, for preventing motion-induced vomiting. That is a different indication. For gastroparesis the agency issued a Complete Response Letter in 2024, and in its March 2026 decision on the hearing request it did not approve the gastroparesis indication. If a site tells you a new drug was approved for gastroparesis, that’s the approval they’re misreading.

So metoclopramide remains the only FDA-approved medication for gastroparesis. Our blog covers the medications patients usually try first and what each one actually does. The meaningful near-term options are procedural, and they hinge entirely on selection.

Are You a Candidate? The 4-Gate Pyloric Screen

Endoscopic pyloromyotomy targets one muscle: the pylorus, the valve between your stomach and small intestine. It helps when that valve is the bottleneck. It does nothing when the problem is somewhere else. So before recommending it, Dr. Grandhige runs a four-gate screen.

Gate 1: A real delay, measured over four hours. A 2-hour study produces false calls in both directions. The AGA now recommends against it. The standard is a 4-hour solid-phase gastric emptying study, and the AGA’s own implementation guidance for G-POEM candidates describes at least a moderate delay, generally around 20 percent retention at four hours on the Eggbeaters test meal. If your only study was two hours long, you don’t yet have an answer.

Gate 2: Symptoms that match the mechanism, and enough history behind them. The cardinal symptoms are nausea, vomiting, and postprandial fullness. AGA guidance describes candidates as having at least 6 to 12 months of moderate symptoms. Abdominal pain as the dominant complaint is a different picture and responds less predictably.

Gate 3: The mimics are ruled out. This is where most consultations stall. Rumination syndrome, esophageal hypersensitivity, functional heartburn, and esophageal motility disorders including achalasia all produce symptoms that read as gastroparesis. So do opioids, GLP-1 agonists, and anticholinergic medications. Cutting a pylorus does not fix any of them.

Gate 4: Medical therapy was actually tried. Both the AGA and every insurer want to see a documented trial of prokinetic and antiemetic therapy before a procedure. Not a two-week attempt. A real trial, with dose adjustment and follow-up.

3D illustration of the stomach and pylorus highlighting where gastroparesis slows emptying, teal and slate tones

Dr. Grandhige’s position on the screen is blunt: the most common reason he does not recommend a pyloric procedure is that something other than the pylorus is driving the symptoms. Those are the hardest conversations in the practice, and they’re also the ones that prevent a patient from carrying a permanent myotomy that was never going to help.

How Endoscopic Pyloromyotomy Compares to the Other Options

Five things get called gastroparesis treatment. They’re not interchangeable.

Endoscopic pyloromyotomy (G-POEM or POP) is done through the mouth with a flexible endoscope. A tunnel is created under the pyloric muscle, the muscle is divided, and the valve stops resisting. No abdominal incisions. Most patients go home the same day and return to normal activity within days on a structured diet progression. A pooled analysis of 13 studies covering 952 patients with refractory gastroparesis reported clinical success of about 72 percent at one year, with roughly 8 percent adverse events. Among patients who succeeded at one year, about 58 percent still had success at three years. Response varies by cause, with published series reporting roughly 64 percent for diabetic, 67 percent for post-surgical, and 72 percent for idiopathic gastroparesis.

Read those numbers the way we present them in the office. Around one in four patients does not respond at a year, and the benefit erodes over time in a subset of the rest. That is why the screen exists.

Surgical pyloroplasty divides and reshapes the same valve through small abdominal incisions. The AGA made no recommendation either way here, identifying it as a knowledge gap in the evidence.

Gastric electrical stimulation (Enterra) is an implanted device. The AGA advises against routine use and reserves it for refractory patients, particularly those with nausea and vomiting as the dominant symptoms. We do not implant these devices, and if that’s the right path for you we will say so and route you appropriately.

One sequencing detail almost nobody mentions: the Enterra enhanced-programming study currently recruiting at the University of South Florida in Tampa (ClinicalTrials.gov identifier NCT06560307, sponsored by Enterra Medical) excludes anyone with a history of pyloroplasty, pyloromyotomy, or G-POEM, and excludes post-surgical gastroparesis. If a trial is something you want to keep on the table, the order you do things in matters. We will tell you that before a procedure, not after.

Feeding tubes and subtotal gastrectomy are reserved for severe malnutrition and disease that has not responded to anything else. The parent gastroparesis page covers the full range in more detail.

Medication remains the starting point for nearly everyone, and for many patients it’s also the ending point.

Why Gastroparesis Gets Mislabeled, and What We Rule Out First

A gastroparesis diagnosis is often a label applied to a symptom cluster rather than a confirmed mechanism. Three patterns come through this practice repeatedly.

Post-surgical gastroparesis. Delayed emptying after foregut or bariatric surgery is a distinct category with a distinct cause, usually vagal nerve injury. It changes what to expect from a pyloric procedure and, as noted above, it changes trial eligibility. Dr. Grandhige routinely evaluates post-surgical foregut complications from operations performed elsewhere, including after fundoplication.

The large hiatal hernia nobody connected to the stomach. This is the observation Dr. Grandhige makes most often that patients have never heard. The larger a hiatal hernia gets, the more likely an atonic stomach develops, and that stomach may or may not recover after the hernia is repaired. If you have a hernia over 3 centimeters and delayed emptying, the sequence of repair versus pyloric procedure is a real clinical decision, not a formality.

Reflux and gastroparesis pointing at each other. Delayed emptying worsens reflux, and reflux symptoms get treated as gastroparesis and the reverse. Sorting the two requires objective testing rather than a symptom inventory. That’s why evaluation here includes pH monitoring, impedance testing, and esophageal manometry where indicated, the same physiologic approach used for GERD and every other foregut condition in the practice.

One more thing worth knowing: where you feel a problem is often not where it is. On a functional barium swallow, the location a patient points to matches the true anatomic location only about 60 percent of the time. A patient feels food sticking in the throat; the study shows the delay is in the distal esophagus. Testing exists because symptoms are unreliable narrators.

Timelines for Wesley Chapel Patients

Here’s the schedule, start to finish.

First consultation: usually within two weeks, always within four. Send your records to info@tampareflux.com before the visit. Dr. Grandhige personally reviews prior endoscopy and pathology reports, pH studies, manometry, barium swallows, imaging, and notes from your gastroenterologist, ENT, pulmonologist, or primary care physician. Records sent in advance turn the first visit into a decision-making visit instead of a data-gathering one. He works from visual diagrams in the room, and patients consistently say the drawings are what made the condition make sense.

If your testing is already complete: one consultation. The plan can often be set that day.

If testing is needed: a second consultation roughly four weeks later to review results and finalize the plan. Two visits, deliberately. Testing is coordinated through a small number of trusted sites so results come back quickly and consistently, and whatever can be done closer to Wesley Chapel gets done there. Testing days are consolidated where possible.

Insurance authorization runs four to six weeks and our office handles the entire submission. Patients who call their own insurer usually slow this down rather than speed it up.

Total: roughly four to eight weeks from first consultation to procedure, depending on where your testing stands.

Procedures are performed at HCA South Tampa Hospital, the only hospital Dr. Grandhige operates at. The same anesthesia team, nursing staff, and surgical technologists work with him on every case. A physician assistant he employs directly assists in every procedure, knows your anatomy and your operation, and stays involved through your recovery. After hours, you reach Dr. Grandhige himself, not an answering service.

Getting to Our South Tampa Office from Wesley Chapel

Dr.Grandhige in a medical setting

We are at 1315 South Howard Avenue, Suite 101, Tampa, FL 33606. Phone: 813-922-2920. Hours: 9:00 AM to 6:00 PM, Monday through Friday.

Wesley Chapel sits roughly 25 miles north of downtown Tampa along the I-75 corridor, and the office is a few miles further south in the SoHo district. From most Wesley Chapel neighborhoods, take SR 56 or SR 54 to I-75 south, then I-275 south to the Howard Avenue exit. Plan on 35 to 45 minutes outside of peak hours and longer if you’re crossing the I-275 corridor during morning or evening rush.

The office is in a yellow brick building next door to Sally O’Neill’s Pizza. Parking is behind the restaurant, not on Howard.

Wesley Chapel has grown from under 6,000 residents in 2000 to more than 70,000 today, and Pasco County now sits above 680,000. Specialty foregut and motility care has not expanded at the same rate, which is why patients from Meadow Pointe, Wiregrass Ranch, Seven Oaks, and the surrounding Pasco communities drive south for it. Patients also travel here from Orlando, Sarasota, Naples, and Jacksonville, and out-of-town scheduling and travel coordination is routine for the office. Dr. Grandhige has practiced in Tampa Bay since 2009. You can read more about his training and background.

Questions Wesley Chapel Patients Ask Most

No. Metoclopramide is still the only FDA-approved medication for gastroparesis. Tradipitant was approved in December 2025 under the brand name Nereus, but for prevention of motion-induced vomiting, not gastroparesis. The FDA did not approve the gastroparesis indication. Naronapride produced positive Phase 2b results in May 2026 and moved into late-stage Phase 3 studies in June 2026, so it is years from any potential approval and is not available by prescription.

Not for this decision. The AGA’s 2025 guideline recommends against 2-hour testing because it produces false results in both directions, and recommends the full 4-hour study instead. If your study was two hours, expect to repeat it before any procedure is discussed.

Not always. Whatever can be done closer to Wesley Chapel gets ordered there when the quality is reliable. Testing that has to happen at one of our trusted sites is scheduled into as few trips as possible.

Yes, meaningfully. Post-surgical gastroparesis usually involves vagal nerve injury rather than pyloric dysfunction alone. It changes expected outcomes and it excludes you from several active clinical trials. Bring your operative report to the consultation.

Most commonly, a cause other than the pylorus. Rumination syndrome, esophageal hypersensitivity, functional heartburn, an untreated motility disorder, or symptoms driven by opioids or GLP-1 medications. A 2-hour-only emptying study, or no documented trial of prokinetic therapy, will also stop the process until those gaps are closed.

It can. The Enterra programming study recruiting at USF in Tampa excludes anyone with a prior pyloromyotomy, pyloroplasty, or G-POEM. If trial participation matters to you, raise it at the first visit so sequencing gets discussed before anything is done.

Usually within two weeks, and always within four.

Endoscopy and pathology reports, pH testing results, manometry, barium swallow or other imaging, office notes from your gastroenterologist, ENT, pulmonologist or allergist, a current medication list, and a list of prior surgeries. Send them to info@tampareflux.com. Studies from years ago are still useful because they show how the condition has progressed.

Medically reviewed by Gopal Grandhige, MD, FACS Board-Certified General Surgeon. Founder and Medical Director, Tampa Bay Reflux Institute. Fellowship training in Foregut and Minimally Invasive Surgery, Yale-New Haven Hospital. General Surgery Residency, Yale-New Haven Hospital. MD, University of Michigan. BS Biology, Johns Hopkins University. Founding Member, American Foregut Society. Member, Society of American Gastrointestinal and Endoscopic Surgeons (SAGES). Fellow, American College of Surgeons. Practicing foregut surgery in Tampa Bay since 2009. Board certification is verifiable through the American Board of Surgery physician lookup and active Florida licensure through the Florida Department of Health Medical Quality Assurance license lookup.

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An endoscopy cannot tell you if you have reflux. It can only tell you if you have complications of GERD. 

If you are unhappy with your reflux symptoms, come in and we can discuss testing and treatments that can accurately diagnose your problem. 

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CALL US AT 813-922-2920
www.tampareflux.com

If you have a hiatal hernia and fit one of these categories, you should know your options. 

Dr. Grandhige is an expert in his field and performs 200 of these surgeries a year.  He is the only surgeon in the Tampa Bay Area who offers all surgical options - LINX, Fundoplications, TIF and will be one of 20 surgeons in America introducing the latest procedure RefluxStop in 2026. 

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What causes reflux ?

1.  Weak lower esophageal sphincter
2.  Hiatal hernia
3.  Flattening of the Angle of His
4.  Poor esophageal motility
5.  Gastroparesis (slow stomach)

NOT increased acid production

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If you are tired of avoiding your favorite foods or taking daily medications, we can help. 

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All major insurances accepted.

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Not all patients need surgical intervention.  Many patients are living a heartburn free life with their PPIs. However 40% of patients taking PPIs are not getting the relief they need.  If you are one of those, you have options!  Come in and find out more. 
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