Endoscopic Pyloromyotomy and What the Long-Term Data Shows
Endoscopic pyloromyotomy, also called G-POEM or POP, cuts the pyloric muscle from inside the stomach using a flexible endoscope passed through the mouth. There are no abdominal incisions. The pylorus is the muscular valve between the stomach and the small intestine, and in many patients with gastroparesis it fails to relax, so cutting it lets food pass more freely.
The durability question matters more than the procedure description, and it has real answers. A 2025 meta-analysis of 23 studies covering 871 patients found clinical response rates that stayed above 70 percent through the first year, reached 79 percent at 24 months, and reached 81 percent at 60 months, with adverse events in 7 percent of cases. A separate pooled analysis put technical success at 98.6 percent and three-year clinical success at 75 percent.
The same analysis identified four factors that predicted lasting benefit: idiopathic rather than diabetic cause, shorter disease duration, a previous response to botulinum toxin injection, and higher baseline symptom severity. Those predictors are part of the candidacy conversation here.
One caution belongs alongside those numbers. Procedures for gastroparesis are aimed at improving symptoms, not at curing the underlying disease. Dr. Grandhige is one of a small number of physicians performing endoscopic pyloromyotomy in the Tampa Bay area, and he also performs robotic and laparoscopic pyloroplasty. For patients with severe weight loss or malnutrition, procedures that vent the stomach or allow feeding directly into the intestine come first, so that nutrition is stable before any definitive procedure is considered.
The Four-Gate Pylorus Check
Four questions have to clear before a pyloromyotomy is recommended here. If any one of them fails, the procedure comes off the table.
Gate 1: Is the delay confirmed on a full four-hour study? A shorter protocol is not a substitute. If your study was two hours, the first step is repeating it correctly.
Gate 2: Has medical therapy been optimized, or only attempted? Tried once and stopped is different from optimized. This gate is where most patients discover they skipped a step.
Gate 3: Is the pylorus the bottleneck, or is something else? Upper endoscopy shows anatomy and damage. Manometry shows whether the esophagus works. A barium swallow shows what happens during an actual swallow. EndoFLIP measures how the valve behaves and allows treatment to be matched to each patient’s anatomy. Symptom location alone is unreliable: in Dr. Grandhige’s experience, where a patient feels food getting stuck matches the true anatomic site only about 60 percent of the time.
Gate 4: Which symptoms should improve, and which will not? Before anything is scheduled, you get an explicit list of the symptoms expected to improve, the ones that may improve partly, and the ones unlikely to be related at all.
As Dr. Grandhige puts it to patients: the operation is the last step, and the decision-making is the surgery.
When Gastroparesis Is Not the Whole Story
Delayed emptying often sits next to another foregut problem, and treating the pylorus alone can leave the real driver untouched. This is the most common reason a patient gets a procedure and still feels unwell.
Gastroparesis produces reflux-like symptoms, and it frequently coexists with gastroesophageal reflux disease. A hiatal hernia larger than three centimeters almost always contributes mechanically, and the larger the hernia, the more likely an atonic stomach develops, which may or may not improve after the hernia is repaired. Achalasia and other motility disorders can present with chest discomfort, regurgitation, and early fullness that look like gastroparesis until manometry separates them. Throat clearing, hoarseness, and chronic cough may point to laryngopharyngeal reflux rather than to the stomach. Rumination, esophageal hypersensitivity, and functional disorders can mimic all of it and are not surgically correctable.
Because Dr. Grandhige treats the full range of benign esophagus, diaphragm, and stomach conditions, these are sorted out in one evaluation rather than across four referrals.
He is also direct about the outcome patients like least. The patients he declines to operate on are often the most frustrated people who leave the office. They are also the patients who would be far more frustrated after an operation that did not change their symptoms.
Your Surgeon and Your Team
Gopal Grandhige, MD is a board-certified general surgeon with fellowship training in foregut and minimally invasive surgery. He completed a Bachelor of Science in Biology at Johns Hopkins University, his medical degree at the University of Michigan, and his general surgery residency at Yale-New Haven Hospital, followed by fellowships in burn and critical care and in foregut and minimally invasive surgery, also at Yale-New Haven. He is a Fellow of the American College of Surgeons, a member of the Society of American Gastrointestinal and Endoscopic Surgeons, and a founding member of the American Foregut Society. More detail is on the about the practice page.
He founded Tampa Bay Reflux Center in 2009 and Tampa Bay Reflux Institute in 2022, and he has held surgical privileges at HCA Brandon Hospital along with three other area hospitals. All foregut procedures are performed at HCA South Tampa Hospital, with the same operating room team and the same anesthesiologists on every case.
His physician assistant assists in every procedure, knows each patient’s anatomy and operative details, and is reachable during recovery. Several of the office medical assistants have worked with him for more than a decade. After hours, patients can reach Dr. Grandhige directly.
You can confirm his active Florida medical license and any disciplinary history through the Florida Department of Health license verification portal.

Getting to the Office From Brandon
Common Questions From Brandon Patients
Start with the testing that answers the question
You do not need another prescription trial to find out whether your pylorus is the problem. You need a four-hour study read correctly, the right motility testing, and someone who will tell you plainly which symptoms a procedure will and will not fix.
Medically reviewed by Gopal Grandhige, MD, FACS. Board-certified general surgeon, fellowship-trained in foregut and minimally invasive surgery. Founder and Medical Director, Tampa Bay Reflux Institute. Practicing in Tampa Bay since 2009.
This page is for general education and does not replace a consultation. Treatment decisions for gastroparesis depend on individual testing, anatomy, and medical history.
An endoscopy cannot tell you if you have reflux. It can only tell you if you have complications of GERD.
If you are unhappy with your reflux symptoms, come in and we can discuss testing and treatments that can accurately diagnose your problem.
#reflux #gerd #hiatalhernia #gastroparesis #linx
CALL US AT 813-922-2920
www.tampareflux.com
If you have a hiatal hernia and fit one of these categories, you should know your options.
Dr. Grandhige is an expert in his field and performs 200 of these surgeries a year. He is the only surgeon in the Tampa Bay Area who offers all surgical options - LINX, Fundoplications, TIF and will be one of 20 surgeons in America introducing the latest procedure RefluxStop in 2026.
We accept most insurances but will verify yours before you come in. These procedures are considered medically necessary and covered by your insurance. You can expect to pay your in-network deductibles and nothing else.
#hiatalhernia #reflux #GERD #LINX #refluxstop
What causes reflux ?
1. Weak lower esophageal sphincter
2. Hiatal hernia
3. Flattening of the Angle of His
4. Poor esophageal motility
5. Gastroparesis (slow stomach)
NOT increased acid production
Don’t let GERD get in the way of living your life. Request your appointment with us today on the link below.
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https://tampareflux.com/contact-us/
Anyone can be victim to GERD and though weight loss can help reduce GERD symptoms. Many athletes with high impact workouts may continue to have these symptoms. This may be a symptom of a hiatal hernia or other issue. We are more then happy to assist you in finding your solution, just click the link below.
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https://tampareflux.com/contact-us/
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Heartburn may seem like an annoyance. But if you find yourself having symptoms on a daily basis, it may be time to to talk to Dr. Grandhige as it could be a symptom of something worse.
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If you are tired of avoiding your favorite foods or taking daily medications, we can help.
We are the Tampa experts in reflux ! With years of experience and thousands of patients treated successfully, we offer all FDA approved anti-reflux procedures.
Call 813-922-2920 to schedule your appointment
All major insurances accepted.
Not all patients need surgical intervention. Many patients are living a heartburn free life with their PPIs. However 40% of patients taking PPIs are not getting the relief they need. If you are one of those, you have options! Come in and find out more.
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