Are You a Candidate? The 4-Gate Pyloric Screen
Endoscopic pyloromyotomy targets one muscle: the pylorus, the valve between your stomach and small intestine. It helps when that valve is the bottleneck. It does nothing when the problem is somewhere else. So before recommending it, Dr. Grandhige runs a four-gate screen.
Gate 1: A real delay, measured over four hours. A 2-hour study produces false calls in both directions. The AGA now recommends against it. The standard is a 4-hour solid-phase gastric emptying study, and the AGA’s own implementation guidance for G-POEM candidates describes at least a moderate delay, generally around 20 percent retention at four hours on the Eggbeaters test meal. If your only study was two hours long, you don’t yet have an answer.
Gate 2: Symptoms that match the mechanism, and enough history behind them. The cardinal symptoms are nausea, vomiting, and postprandial fullness. AGA guidance describes candidates as having at least 6 to 12 months of moderate symptoms. Abdominal pain as the dominant complaint is a different picture and responds less predictably.
Gate 3: The mimics are ruled out. This is where most consultations stall. Rumination syndrome, esophageal hypersensitivity, functional heartburn, and esophageal motility disorders including achalasia all produce symptoms that read as gastroparesis. So do opioids, GLP-1 agonists, and anticholinergic medications. Cutting a pylorus does not fix any of them.
Gate 4: Medical therapy was actually tried. Both the AGA and every insurer want to see a documented trial of prokinetic and antiemetic therapy before a procedure. Not a two-week attempt. A real trial, with dose adjustment and follow-up.

Dr. Grandhige’s position on the screen is blunt: the most common reason he does not recommend a pyloric procedure is that something other than the pylorus is driving the symptoms. Those are the hardest conversations in the practice, and they’re also the ones that prevent a patient from carrying a permanent myotomy that was never going to help.
How Endoscopic Pyloromyotomy Compares to the Other Options
Five things get called gastroparesis treatment. They’re not interchangeable.
Endoscopic pyloromyotomy (G-POEM or POP) is done through the mouth with a flexible endoscope. A tunnel is created under the pyloric muscle, the muscle is divided, and the valve stops resisting. No abdominal incisions. Most patients go home the same day and return to normal activity within days on a structured diet progression. A pooled analysis of 13 studies covering 952 patients with refractory gastroparesis reported clinical success of about 72 percent at one year, with roughly 8 percent adverse events. Among patients who succeeded at one year, about 58 percent still had success at three years. Response varies by cause, with published series reporting roughly 64 percent for diabetic, 67 percent for post-surgical, and 72 percent for idiopathic gastroparesis.
Read those numbers the way we present them in the office. Around one in four patients does not respond at a year, and the benefit erodes over time in a subset of the rest. That is why the screen exists.
Surgical pyloroplasty divides and reshapes the same valve through small abdominal incisions. The AGA made no recommendation either way here, identifying it as a knowledge gap in the evidence.
Gastric electrical stimulation (Enterra) is an implanted device. The AGA advises against routine use and reserves it for refractory patients, particularly those with nausea and vomiting as the dominant symptoms. We do not implant these devices, and if that’s the right path for you we will say so and route you appropriately.
One sequencing detail almost nobody mentions: the Enterra enhanced-programming study currently recruiting at the University of South Florida in Tampa (ClinicalTrials.gov identifier NCT06560307, sponsored by Enterra Medical) excludes anyone with a history of pyloroplasty, pyloromyotomy, or G-POEM, and excludes post-surgical gastroparesis. If a trial is something you want to keep on the table, the order you do things in matters. We will tell you that before a procedure, not after.
Feeding tubes and subtotal gastrectomy are reserved for severe malnutrition and disease that has not responded to anything else. The parent gastroparesis page covers the full range in more detail.
Medication remains the starting point for nearly everyone, and for many patients it’s also the ending point.
Getting to Our South Tampa Office from Wesley Chapel

We are at 1315 South Howard Avenue, Suite 101, Tampa, FL 33606. Phone: 813-922-2920. Hours: 9:00 AM to 6:00 PM, Monday through Friday.
Wesley Chapel sits roughly 25 miles north of downtown Tampa along the I-75 corridor, and the office is a few miles further south in the SoHo district. From most Wesley Chapel neighborhoods, take SR 56 or SR 54 to I-75 south, then I-275 south to the Howard Avenue exit. Plan on 35 to 45 minutes outside of peak hours and longer if you’re crossing the I-275 corridor during morning or evening rush.
The office is in a yellow brick building next door to Sally O’Neill’s Pizza. Parking is behind the restaurant, not on Howard.
Wesley Chapel has grown from under 6,000 residents in 2000 to more than 70,000 today, and Pasco County now sits above 680,000. Specialty foregut and motility care has not expanded at the same rate, which is why patients from Meadow Pointe, Wiregrass Ranch, Seven Oaks, and the surrounding Pasco communities drive south for it. Patients also travel here from Orlando, Sarasota, Naples, and Jacksonville, and out-of-town scheduling and travel coordination is routine for the office. Dr. Grandhige has practiced in Tampa Bay since 2009. You can read more about his training and background.
Questions Wesley Chapel Patients Ask Most
Medically reviewed by Gopal Grandhige, MD, FACS Board-Certified General Surgeon. Founder and Medical Director, Tampa Bay Reflux Institute. Fellowship training in Foregut and Minimally Invasive Surgery, Yale-New Haven Hospital. General Surgery Residency, Yale-New Haven Hospital. MD, University of Michigan. BS Biology, Johns Hopkins University. Founding Member, American Foregut Society. Member, Society of American Gastrointestinal and Endoscopic Surgeons (SAGES). Fellow, American College of Surgeons. Practicing foregut surgery in Tampa Bay since 2009. Board certification is verifiable through the American Board of Surgery physician lookup and active Florida licensure through the Florida Department of Health Medical Quality Assurance license lookup.
An endoscopy cannot tell you if you have reflux. It can only tell you if you have complications of GERD.
If you are unhappy with your reflux symptoms, come in and we can discuss testing and treatments that can accurately diagnose your problem.
#reflux #gerd #hiatalhernia #gastroparesis #linx
CALL US AT 813-922-2920
www.tampareflux.com
If you have a hiatal hernia and fit one of these categories, you should know your options.
Dr. Grandhige is an expert in his field and performs 200 of these surgeries a year. He is the only surgeon in the Tampa Bay Area who offers all surgical options - LINX, Fundoplications, TIF and will be one of 20 surgeons in America introducing the latest procedure RefluxStop in 2026.
We accept most insurances but will verify yours before you come in. These procedures are considered medically necessary and covered by your insurance. You can expect to pay your in-network deductibles and nothing else.
#hiatalhernia #reflux #GERD #LINX #refluxstop
What causes reflux ?
1. Weak lower esophageal sphincter
2. Hiatal hernia
3. Flattening of the Angle of His
4. Poor esophageal motility
5. Gastroparesis (slow stomach)
NOT increased acid production
Don’t let GERD get in the way of living your life. Request your appointment with us today on the link below.
.
.
.
.
https://tampareflux.com/contact-us/
Anyone can be victim to GERD and though weight loss can help reduce GERD symptoms. Many athletes with high impact workouts may continue to have these symptoms. This may be a symptom of a hiatal hernia or other issue. We are more then happy to assist you in finding your solution, just click the link below.
.
.
.
https://tampareflux.com/contact-us/
##healthylifestyle #workout #athletereflux #PPIs #heartburn #LINX #fundoplication #TIF #GERD#tampaheartburn #linx #TIF #fundoplication #tampabayreflux #GERD #acidreflux #acidrefluxsurgery #stopreflux
#nonsurgicalweightloss #ESG #gastricballoon #weightlossjourney #vsg #vsgjourney #spatz3 #orbera #orberaballoon #grandhige #DrG
#tampabayrefluxinstitute #guthealth #roboticsurgery
Heartburn may seem like an annoyance. But if you find yourself having symptoms on a daily basis, it may be time to to talk to Dr. Grandhige as it could be a symptom of something worse.
.
.
.
#chronicheartburn #gerdsymptoms #heartburnrelief #reflux #PPIs #heartburn #LINX #fundoplication #TIF #GERD#tampaheartburn #linx #TIF #fundoplication #tampabayreflux #GERD #acidreflux #acidrefluxsurgery #stopreflux
#nonsurgicalweightloss #ESG #gastricballoon #weightlossjourney #vsg #vsgjourney #spatz3 #orbera #orberaballoon #grandhige #DrG
#tampabayrefluxinstitute #guthealth #roboticsurgery
If you are tired of avoiding your favorite foods or taking daily medications, we can help.
We are the Tampa experts in reflux ! With years of experience and thousands of patients treated successfully, we offer all FDA approved anti-reflux procedures.
Call 813-922-2920 to schedule your appointment
All major insurances accepted.
Not all patients need surgical intervention. Many patients are living a heartburn free life with their PPIs. However 40% of patients taking PPIs are not getting the relief they need. If you are one of those, you have options! Come in and find out more.
.
.
.
.
#letushelpyou #medsnotworking #reflux #PPIs #heartburn #LINX #fundoplication #TIF #GERD#tampaheartburn #linx #TIF #fundoplication #tampabayreflux #GERD #acidreflux #acidrefluxsurgery #stopreflux
#nonsurgicalweightloss #ESG #gastricballoon #weightlossjourney #vsg #vsgjourney #spatz3 #orbera #orberaballoon #grandhige #DrG
#tampabayrefluxinstitute #guthealth #roboticsurgery
#heartburn #stopreflux #hiatalherniarepair #severeheartburn #reflux #tampabayreflux #acidrefluxsurgery #tampaheartburn #GERD #PPIs #achalasia #LINX #TIF #tampareflux #fundoplication #stomach #digestivehealth #ESG #obesity #overweight #weightlossjourney #gastricballoon